Difference between revisions of "CHEM-5181"

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*(Various Topics, Advanced) [http://www.asms.org/Default.aspx?tabid=190 Selected Award/Plenary/Tutorial Lectures from the Annual Conferences of the American Society of Mass Spectrometry]  
 
*(Various Topics, Advanced) [http://www.asms.org/Default.aspx?tabid=190 Selected Award/Plenary/Tutorial Lectures from the Annual Conferences of the American Society of Mass Spectrometry]  
 
*(General, Reference, Hard Copy at Libraries): [http://libraries.colorado.edu/record=b3604631 Encyclopedia of Mass Spectrometry]
 
*(General, Reference, Hard Copy at Libraries): [http://libraries.colorado.edu/record=b3604631 Encyclopedia of Mass Spectrometry]
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===Ionization Methods===
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*(General, Reference) [http://pubs3.acs.org/acs/journals/doilookup?in_doi=10.1021/cr990104w Methods of Ion Generation] M. L. Vestal, <i>Chem. Rev.</i>, 101(2), 361, 2001.
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*(General, Reference) [http://www.pnas.org/cgi/content/abstract/91/24/11290 The Emergence of Mass Spectrometry in Biochemical Research] G. Siuzdak, <i>Proc. Natl. Acad. Sci. USA</i>, 91(24), 11290, 1994.
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*(EI, Advanced) [http://books.google.com/books?id=TA5N2svGCK4C&lpg=PA1&ots=VkoweozDrO&dq=Fundamental%20Electron%20Interactions%20with%20Plasma%20Processing%20Gases Fundamentals of Electron Interactions with Plasma Processing Gases], by L.G. Christophorou, J.K. Olthoff, Springer, 2004.
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*(CI, Advanced) [http://pubs.acs.org/cgi-bin/archive.cgi/jacsat/1966/88/i12/pdf/ja00964a001.pdf Chemical Ionization Mass Spectrometry. I.  General Introduction]. M.S.B. Munson and F.H. Field, <i>J. Am. Chem. Soc.</i>, 2621, 1966.
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*(ESI, Advanced) [http://www3.interscience.wiley.com/cgi-bin/abstract/93518527/ABSTRACT Practical implications of some recent studies in electrospray ionization fundamentals]. Cech and Enke, <i>Mass Spec. Rev.</i>, 20: 362-387, 2002.
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*(ESI, Advanced) [http://www3.interscience.wiley.com/cgi-bin/abstract/72512664/ABSTRACT  A brief overview of the present status of the mechanisms involved in electrospray mass spectrometry] P. Kebarle, <i>J.Mass Spec.</i>,804-817, 2000.
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*(ESI, Advanced) [http://www3.interscience.wiley.com/journal/122463140/abstract Electrospray: From ions in solution to ions in the gas phase, what we know now]. P. Kebarle and U.H. Verkerk, <i>Mass Spec. Rev.</i> doi: 10.1002/mas.20247, 2009.
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*(ESI, Advanced) [http://www3.interscience.wiley.com/cgi-bin/abstract/72512616/ABSTRACT Some tenets pertaining to ESI-MS] R. B. Cole, <i>J. Mass Spec.</i>,763-772,2000. 
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*(ESI, Advanced) [http://pubs.acs.org/cgi-bin/abstract.cgi/ancham/1996/68/i01/abs/ac9509519.html Analytical Properties of the Nanoelectrospray Ion Source] M. Wilm and M. Mann, <i>A. Chem.</i>, 1-8, 1996.
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*(MALDI & ESI, Reference) [http://nobelprize.org/nobel_prizes/chemistry/laureates/2002/chemadv02.pdf Mass spectrometry and nuclear magnetic resonance applied to biological macromolecules.] Advanced Information on the Nobel Prize in Chemistry 2002.
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*(MALDI, ESI, Suggested) [http://www.hopkinsmedicine.org/mams/MAMS/middleframe_files/teaching_files/ME330.884/2005/MS2005-Lecture-2-Basic-MALDI-ESI.pdf MALDI & ESI lecture from Prof. Cotter]
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*(MADLI, Suggested) [http://www.mc.vanderbilt.edu/msrc/tutorials/MALDI_MS_Tutorial.pdf MALDI Tutorial from Vanderbilt]
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*(MALDI, Advanced) [http://www3.interscience.wiley.com/cgi-bin/abstract/61005725/ABSTRACT Ion formation in MALDI mass spectrometry]. Zenobi and Knochenmuss, <i>Mass. Spec. Rev.</i>, 17: 337-366, 1999.
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*(MALDI, Advanced) [http://pubs3.acs.org/acs/journals/doilookup?in_doi=10.1021/ac990998k Atmospheric Pressure Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry] V. V. Laiko, M. A. Baldwin, and A. L. Burlingame, <i>A. Chem.</i>,652-657, 2000.
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*(SIMS, Advanced) [http://www.eaglabs.com/en-US/references/tutorial/simstheo/caistheo.html SIMS Tutorial] On Evans Analytical Group Website
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*(DESI, Advanced) [http://www3.interscience.wiley.com/cgi-bin/abstract/112126895/ABSTRACT Ambient mass spectrometry using desorption electrospray ionization (DESI): instrumentation, mechanisms and applications in forensics, chemistry, and biology] Z. Takats, J. M. Wiseman, and R. G. Cooks, <i>J. Mass Spec.</i>,1261-1275, 2005.
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*(DART, Advanced) [http://pubs.acs.org/cgi-bin/abstract.cgi/ancham/2005/77/i08/abs/ac050162j.html Versatile New Ion Source for the Analysis of Materials in Open Air under Ambient Conditions] R. B. Cody, J. A. Laramee, H. D. Durst, <i>A. Chem.</i>, 2297-2303, 2005.
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<li>(Atm. Pres. Ion Sources, Advanced) <a href="http://www3.interscience.wiley.com/journal/122518620/abstract">Atmospheric Pressure Ion Sources</a>. <i>Mass Spec. Rev.</i>, doi: 10.1002/mas.20246, 2009.
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<li>(Elemental, Advanced) <a href = "http://scitation.aip.org/getabs/servlet/GetabsServlet?prog=normal&id=RSINAK000024000007000518000001&idtype=cvips&gifs=yes">Surface Ionization Source Using Multiple Elements</a> M. G. Inghram and W. A. Chupka <i>Rev. Sci. Inst.</i>,24(7), 518, 1953.
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<li>(Elemental, Advanced) <a href ="http://pubs.acs.org/cgi-bin/abstract.cgi/ancham/2005/77/i08/abs/ac050162j.html">Recent Developments in Thermal Ionization Mass Spectrometric Techniques for Isotope Analyis</a> K.G. Heumann et al, <i>Analyst</i>, 1291, 1995.
 +
<li>(Elemental, Advanced) <a href="http://www3.interscience.wiley.com/cgi-bin/abstract/110464831/ABSTRACT">Tutorial. Glow discharge mass spectrometry: Trace element determinations in solid samples.</a> King et al., <i>J. Mass. Spec.</i>, 30: 1061-1075 <a href = "Restricted/GlowDischarge_King_JMS1995.PDF">(pdf)</a>
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<li>(Elemental, Advanced) <a href="http://www3.interscience.wiley.com/cgi-bin/abstract/114201969/ABSTRACT">Tutorial. Inductively coupled plasma mass spectrometry (ICP MS): a versatile tool.</a> A. Ammann, <i>J. Mass. Spec.</i>, 42: 419-427, 2007.

Revision as of 12:01, 16 December 2010

This is the new home for the CU-Boulder Graduate Course CHEM-5181: Mass Spectrometry and Chromatography

  • The old web page is located here, and I'll be gradually move things over to this Wiki page, which is much easier to update.

Course Information

  • This course WILL be offered in Fall 2011, and WILL NOT be offered in Fall 2012
  • Fall 2010 Syllabus
  • Registering for the course:
    • Every CU student attending the course needs to register, either as (a) for grade; (b) for pass/fail; or (c) for "Audit/No Credit".
    • For non-CU students, you can register for the course through the CU Continuing Education Program ("ACCESS"), again as either (a) for grade; (b) for pass/fail; or (c) for "Audit/No Credit".
  • Lectures: Tue & Thu 11:00-12:15, Ekeley W166
  • Labs: to be determined, based on the student and MS facility schedules (typically three Tue afternoons 1-3 pm)
  • Office hours: immediately after class on Tue & Thu
  • Textbooks:
    • de Hoffmann & Stroobant. Mass Spectrometry, Principles and Applications, 3rd. Ed. ISBN: 0471485667; Library: QD96.M3 H6413 2007
    • McLafferty & Turecek Interpretation of Mass Spectra, 4th Ed., ISBN: 0935702253; Library: QC454.M22 1993;

FAQs about CHEM-5181

  • Can I audit the class?
    • Answer: Yes, but you need to register for it as "Audit / No Credit", either as a regular CU student or through the ACCESS Program. Auditors typically attend lectures but do not do the labs, homeworks, or exams, unless they want to.
  • But I don't want to register at all. Can I still audit the class?
    • Answer: No.
  • I work in industry and use MS and chromatography in my work, can I take the class?
    • Answer: Yes, registering through the ACCESS Program. Some things to think about: (a) you need to have the relevant background or be willing to work to gain the background, especially if you want to take the class for credit. (b) This is a class for 1st year graduate students in Anaytical & Environmental Chemistry, and it takes quite a bit of work to take the class for credit. If you don't have much time for the class due to your work responsibilities, you should register as "Audit / No Credit".

Lectures

Introduction, Review, Igor

Mass Spectrometers

  • 3D Ion Traps
    • Required Reading: de Hoffmann and Stroobant 2007, Section 2.2

Ionization Sources

MS Detectors, Data Acquisition, Vacuum

  • Vacuum Technology
    • Props: turbo pump, diaphragm pump

MS Interpretation

  • Interpretation of Mass Spectra III (The Molecular Ion)
    • Required Reading: McLafferty and Turecek 1993, Chapters 3 and 5
  • Interpretation of Mass Spectra IV (Fragmentation Mechanisms)
    • Required Reading: McLafferty and Turecek 1993, Chapters 4, and skim 9

Chromatography and Chemical Separations

  • Gas Chromatography
    • Prop: GC column
  • LC and HPLC
  • Ion Chromatography & Thin Layer Chromatography
  • Chromatographic Detectors

Homeworks

Reference material for homeworks

HW on Intro and Review of Fundamentals

HW on TOFMS

HW on Resolution & Accuracy

HW on Quadrupoles

HW on Ion Optics

Labs

Lab 1: MALDI-TOFMS

Lab 2: Electrospray MS

Lab 3: GC-MS of mixtures

Reference Materials

Suggestions Encouraged. Please send links to jose.jimenez at colorado.edu (All .pdf's are password restricted)

Introduction to Mass Spectrometry

Ionization Methods

  • (Atm. Pres. Ion Sources, Advanced) <a href="http://www3.interscience.wiley.com/journal/122518620/abstract">Atmospheric Pressure Ion Sources</a>. Mass Spec. Rev., doi: 10.1002/mas.20246, 2009.
  • (Elemental, Advanced) <a href = "http://scitation.aip.org/getabs/servlet/GetabsServlet?prog=normal&id=RSINAK000024000007000518000001&idtype=cvips&gifs=yes">Surface Ionization Source Using Multiple Elements</a> M. G. Inghram and W. A. Chupka Rev. Sci. Inst.,24(7), 518, 1953.
  • (Elemental, Advanced) <a href ="http://pubs.acs.org/cgi-bin/abstract.cgi/ancham/2005/77/i08/abs/ac050162j.html">Recent Developments in Thermal Ionization Mass Spectrometric Techniques for Isotope Analyis</a> K.G. Heumann et al, Analyst, 1291, 1995.
  • (Elemental, Advanced) <a href="http://www3.interscience.wiley.com/cgi-bin/abstract/110464831/ABSTRACT">Tutorial. Glow discharge mass spectrometry: Trace element determinations in solid samples.</a> King et al., J. Mass. Spec., 30: 1061-1075 <a href = "Restricted/GlowDischarge_King_JMS1995.PDF">(pdf)</a>
  • (Elemental, Advanced) <a href="http://www3.interscience.wiley.com/cgi-bin/abstract/114201969/ABSTRACT">Tutorial. Inductively coupled plasma mass spectrometry (ICP MS): a versatile tool.</a> A. Ammann, J. Mass. Spec., 42: 419-427, 2007.
    • Retrieved from "http://cires1.colorado.edu/jimenez-group/wiki/index.php?title=CHEM-5181&oldid=7753"