Difference between revisions of "CHEM-5181"

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(Mass Spectrometry Societies)
(CU Mass Spec Facility Instruments)
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*Fall 2003: Melinda Beaver (PhD Chemistry, Tolbert group)
 
*Fall 2003: Melinda Beaver (PhD Chemistry, Tolbert group)
 
*Fall 2002: Aaron Appel (PhD Chemistry, Rakowski-Dubois group)
 
*Fall 2002: Aaron Appel (PhD Chemistry, Rakowski-Dubois group)
 
==CU Mass Spec Facility Instruments==
 
 
DISCLAIMER: These pages are not the official pages of the CU MS facility, rather they were created by the CHEM-5181 students as a class assignment, and may contain inaccuracies or errors. (the journal papers are password protected to minimize copyright issues).
 
 
===ThermoFinnigan LCQ Classic===
 
 
*CU MS-Facility nickname: "Q-Trap"
 
*[http://www.colorado.edu/chemistry/chem5181/ThermoFinnigan LCQ.pdf Instrument Description]
 
*[http://www.colorado.edu/chemistry/chem5181/Finnigan_LCQ_Interviews.pdf User Interviews]
 
*[http://www.colorado.edu/chemistry/chem5181/Finnigan_LCQ_Papers.pdf Journal papers that used this instrument]
 
*[http://www.colorado.edu/chemistry/chem5181/Restricted/LCQ_Paper1.pdf Paper #1]
 
*[http://www.colorado.edu/chemistry/chem5181/Restricted/LCQ_Paper2.pdf Paper #2]
 
*[http://www.colorado.edu/chemistry/chem5181/Restricted/LCQ_Paper3.pdf Paper #3]
 
 
===MDS SCIEX/Applied Biosystems API Q-Star Pulsar===
 
 
*CU MS-Facility nickname: "Pulsar" or "Q-TOF"
 
*[http://www.colorado.edu/chemistry/chem5181/QSTAR Pulsar.pdf Instrument Description]
 
*[http://www.colorado.edu/chemistry/chem5181/QStar_Pulsar_Interviews.pdf User Interviews]
 
*[http://www.colorado.edu/chemistry/chem5181/QStar_Pulsar_Papers.pdf  Journal papers that used this instrument]
 
*[http://www.colorado.edu/chemistry/chem5181/Restricted/Pulsar_Paper1.pdf Paper #1]
 
*[http://www.colorado.edu/chemistry/chem5181/Restricted/Pulsar_Paper2.pdf Paper #2]
 
*[http://www.colorado.edu/chemistry/chem5181/Restricted/Pulsar_Paper3.pdf Paper #3]
 
*[http://www.colorado.edu/chemistry/chem5181/Restricted/Pulsar_Paper4.pdf Paper #4] & [http://www.colorado.edu/chemistry/chem5181/Pulsar_Paper4_Supp.pdf Supplement]
 
*[http://www.colorado.edu/chemistry/chem5181/Restricted/Pulsar_Paper5.pdf Paper #5]
 
*[http://www.colorado.edu/chemistry/chem5181/Restricted/Pulsar_Paper6.pdf Paper #6]
 
*[http://www.colorado.edu/chemistry/chem5181/Restricted/Pulsar_Paper7.pdf Paper #7]
 
*[http://www.colorado.edu/chemistry/chem5181/Restricted/Pulsar_Paper8.pdf Paper #8]
 
*[http://www.colorado.edu/chemistry/chem5181/Restricted/Pulsar_Paper9.pdf Paper #9]
 
 
===Hewlett Packard(Agilent) 5988A GC/MS===
 
 
*CU MS-Facility nickname: "GC/MS"
 
*[http://www.colorado.edu/chemistry/chem5181/HP_GCMS.pdf Instrument Description]
 
*[http://www.colorado.edu/chemistry/chem5181/HP_GCMS_Interviews.pdf User Interviews]
 
*[http://www.colorado.edu/chemistry/chem5181/HP_GCMS_Papers.pdf Journal papers that used this instrument]
 
*[http://www.colorado.edu/chemistry/chem5181/Restricted/HP_GCMS_Paper1.pdf Paper #1]
 
*[http://www.colorado.edu/chemistry/chem5181/Restricted/HP_GCMS_Paper2.pdf Paper #2]
 
*[http://www.colorado.edu/chemistry/chem5181/Restricted/HP_GCMS_Paper3.pdf Paper #3]
 
*[http://www.colorado.edu/chemistry/chem5181/Restricted/HP_GCMS_Paper4.pdf Paper #4]
 
*[http://www.colorado.edu/chemistry/chem5181/Restricted/HP_GCMS_Paper5.pdf Paper #5]
 
*[http://www.colorado.edu/chemistry/chem5181/Restricted/HP_GCMS_Paper6.pdf Paper #6]
 
*[http://www.colorado.edu/chemistry/chem5181/Restricted/HP_GCMS_Paper7.pdf Paper #7]
 
*[http://www.colorado.edu/chemistry/chem5181/Restricted/HP_GCMS_Paper8.pdf Paper #8]
 
*[http://www.colorado.edu/chemistry/chem5181/Restricted/HP_GCMS_Paper9.pdf Paper #9]
 
*[http://www.colorado.edu/chemistry/chem5181/Restricted/HP_GCMS_Paper10.pdf Paper #10]
 
*[http://www.colorado.edu/chemistry/chem5181/Restricted/HP_GCMS_Paper11.pdf Paper #11]
 
*[http://www.colorado.edu/chemistry/chem5181/Restricted/HP_GCMS_Paper12.pdf Paper #12]
 
 
===Hewlett-Packard 5989 Electrospray/MS===
 
 
*CU MS-Facility nickname: "ESI"
 
*[http://www.colorado.edu/chemistry/chem5181/HP_ESI.pdf Instrument Description]
 
*[http://www.colorado.edu/chemistry/chem5181/HP_ESI_Interviews.pdf User Interviews]
 
*[http://www.colorado.edu/chemistry/chem5181/HP_ESI_Papers.pdf Journal papers that used this instrument]
 
*[http://www.colorado.edu/chemistry/chem5181/Restricted/HP_ESI_Paper1.pdf Paper #1]
 
*[http://www.colorado.edu/chemistry/chem5181/Restricted/HP_ESI_Paper2.pdf Paper #2]
 
 
===Applied Biosystems Voyager-DE<sup>TM</sup> STR Biospectrometry<sup>TM</sup> Workstation - MALDI TOF-MS===
 
 
*CU MS-Facility nickname: "MALDI" or "Voyager"
 
*[http://www.colorado.edu/chemistry/chem5181/Voyager.pdf Instrument Description]
 
*[http://www.colorado.edu/chemistry/chem5181/Voyager_MALDI_Interviews.pdf User Interviews]
 
*[http://www.colorado.edu/chemistry/chem5181/Voyager_MALDI_Papers.pdf Journal papers that used this instrument]
 
*[http://www.colorado.edu/chemistry/chem5181/Restricted/Voyager_MALDI_Paper1.pdf Paper #1]
 
*[http://www.colorado.edu/chemistry/chem5181/Restricted/Voyager_MALDI_Paper2.pdf Paper #2]
 
*[http://www.colorado.edu/chemistry/chem5181/Restricted/Voyager_MALDI_Paper3.pdf Paper #3]
 
*[http://www.colorado.edu/chemistry/chem5181/Restricted/Voyager_MALDI_Paper4.pdf Paper #4]
 
 
===VG Autospec M===
 
*CU MS-Facility nickname: "Sector" or "Autospec"
 
*[http://www.colorado.edu/chemistry/chem5181/VGAutospecM.html Instrument Description]
 
*[http://www.colorado.edu/chemistry/chem5181/VG_Autospec_Interviews.pdf User Interviews]
 
*[http://www.colorado.edu/chemistry/chem5181/VG_Autospec_Papers.pdf Journal papers that used this instrument]
 
*[http://www.colorado.edu/chemistry/chem5181/Restricted/VG_Autospec_Paper1.pdf Paper #1]
 
*[http://www.colorado.edu/chemistry/chem5181/Restricted/VG_Autospec_Paper2.pdf Paper #2]
 
*[http://www.colorado.edu/chemistry/chem5181/Restricted/VG_Autospec_Paper3.pdf Paper #3]
 
*[http://www.colorado.edu/chemistry/chem5181/Restricted/VG_Autospec_Paper4.pdf Paper #4]
 
*[http://www.colorado.edu/chemistry/chem5181/Restricted/VG_Autospec_Paper5.pdf Paper #5]
 
*[http://www.colorado.edu/chemistry/chem5181/Restricted/VG_Autospec_Paper6.pdf Paper #6]
 
*[http://www.colorado.edu/chemistry/chem5181/Restricted/VG_Autospec_Paper7.pdf Paper #7]
 
*[http://www.colorado.edu/chemistry/chem5181/Restricted/VG_Autospec_Paper8.pdf Paper #8]
 
*[http://www.colorado.edu/chemistry/chem5181/Restricted/VG_Autospec_Paper9.pdf Paper #9]
 
*[http://www.colorado.edu/chemistry/chem5181/Restricted/VG_Autospec_Paper10.pdf Paper #10]
 
*[http://www.colorado.edu/chemistry/chem5181/Restricted/VG_Autospec_Paper11.pdf Paper #11]
 
*[http://www.colorado.edu/chemistry/chem5181/Restricted/VG_Autospec_Paper12.pdf Paper #12]
 
  
 
==MS & Chromatography Courses at other Universities==
 
==MS & Chromatography Courses at other Universities==

Revision as of 10:41, 21 December 2010

This is the new home for the CU-Boulder Graduate Course CHEM-5181: Mass Spectrometry and Chromatography

  • The old web page is located here, and I'll be gradually move things over to this Wiki page, which is much easier to update.

Course Information

  • This course WILL be offered in Fall 2011, and WILL NOT be offered in Fall 2012
  • Fall 2010 Syllabus
  • Registering for the course:
    • Every CU student attending the course needs to register, either as (a) for grade; (b) for pass/fail; or (c) for "Audit/No Credit".
    • For non-CU students, you can register for the course through the CU Continuing Education Program ("ACCESS"), again as either (a) for grade; (b) for pass/fail; or (c) for "Audit/No Credit".
  • Lectures: Tue & Thu 11:00-12:15, Ekeley W166
  • Labs: to be determined, based on the student and MS facility schedules (typically three Tue afternoons 1-3 pm)
  • Office hours: immediately after class on Tue & Thu
  • Textbooks:
    • de Hoffmann & Stroobant. Mass Spectrometry, Principles and Applications, 3rd. Ed. ISBN: 0471485667; Library: QD96.M3 H6413 2007
    • McLafferty & Turecek Interpretation of Mass Spectra, 4th Ed., ISBN: 0935702253; Library: QC454.M22 1993;

FAQs about CHEM-5181

  • Can I audit the class?
    • Answer: Yes, but you need to register for it as "Audit / No Credit", either as a regular CU student or through the ACCESS Program. Auditors typically attend lectures but do not do the labs, homeworks, or exams, unless they want to.
  • But I don't want to register at all. Can I still audit the class?
    • Answer: No.
  • I work in industry and use MS and chromatography in my work, can I take the class?
    • Answer: Yes, registering through the ACCESS Program. Some things to think about: (a) you need to have the relevant background or be willing to work to gain the background, especially if you want to take the class for credit. (b) This is a class for 1st year graduate students in Anaytical & Environmental Chemistry, and it takes quite a bit of work to take the class for credit. If you don't have much time for the class due to your work responsibilities, you should register as "Audit / No Credit".

Lectures

Introduction, Review, Igor

Mass Spectrometers

  • 3D Ion Traps
    • Required Reading: de Hoffmann and Stroobant 2007, Section 2.2

Ionization Sources

MS Detectors, Data Acquisition, Vacuum

  • Vacuum Technology
    • Props: turbo pump, diaphragm pump

MS Interpretation

  • Interpretation of Mass Spectra III (The Molecular Ion)
    • Required Reading: McLafferty and Turecek 1993, Chapters 3 and 5
  • Interpretation of Mass Spectra IV (Fragmentation Mechanisms)
    • Required Reading: McLafferty and Turecek 1993, Chapters 4, and skim 9

Chromatography and Chemical Separations

  • Gas Chromatography
    • Prop: GC column
  • LC and HPLC
  • Ion Chromatography & Thin Layer Chromatography
  • Chromatographic Detectors

Homeworks

Reference material for homeworks

HW on Intro and Review of Fundamentals

HW on TOFMS

HW on Resolution & Accuracy

HW on Quadrupoles

HW on Ion Optics

Labs

Lab 1: MALDI-TOFMS

Lab 2: Electrospray MS

Lab 3: GC-MS of mixtures

Reference Materials

Suggestions Encouraged. Please send links to jose.jimenez at colorado.edu (All .pdf's are password restricted)

Introduction to Mass Spectrometry

Ionization Methods

Mass Analyzers

MS Interpretation

Chromatography: General

Electric Field Driven Separations

LC, GC, and IC

Award for the Best Performance in CHEM-5181

  • Fall 2009: Eleanor Waxman (PhD Chemistry, Volkamer group)
  • Fall 2007: Sean Coburn (PhD Chemistry, Volkamer group)
  • Fall 2006: Jesse Marcum (PhD Chemistry, Weber group)
  • Fall 2004: Steve Dutton (PhD Mechanical Engineering, Hannigan group)
  • Fall 2003: Melinda Beaver (PhD Chemistry, Tolbert group)
  • Fall 2002: Aaron Appel (PhD Chemistry, Rakowski-Dubois group)

MS & Chromatography Courses at other Universities

MS Links

Analytical Chemistry Journals

Mass Spectrometry Journals

Chromatography and Analytical Separations Journals

Mass Spectrometry Societies